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How to take Oxytocin to terminate a pregnancy. How oxytocin causes periods

The drug helps the uterus contract by increasing muscle tone. "Oxytocin" has been successfully used to terminate pregnancy modern medicine. The hormone lowers the pressure in the arterial vessels, so “Oxytocin” for termination of pregnancy is early stages should only be used under medical supervision.

On the shelves in pharmacies you can find its analogues - "Syntocinon", "Pitupartin". When using them, you need to consult a doctor, who will either replace the drug with its analogues or insist on using Oxytocin according to medical indications.

During fertilization, the egg is weakly attached to the walls of the uterus for up to 12 weeks, so it is important for a pregnant woman to use the drug “Oxytocin” during this period. Such a miscarriage in the early stages is called induced. If possible, remove it with medication unwanted pregnancy, then it is better to do this without resorting to surgical abortion. After taking medication, a woman’s body will recover faster.

Oxytocin is available in the form of tablets and injections. In case of unwanted pregnancy, injections are used intramuscularly or intravenously, and only under the supervision of doctors in a hospital. Tablets are prescribed to nursing mothers to enhance lactation and bring the uterus into prenatal shape after the birth of the child. Tablets are not suitable for medical abortion, because the active components of “Oxytocin” are destroyed in the stomach, without reaching the desired destination.

The doctor prescribes a dosage of 0.5 IU intramuscularly, and the drug is administered intravenously through a dropper in a dosage of 1 to 3 IU, 10-20 drops per minute. If side effects are noticed in the hospital, the medical staff stops supplying the medicine. The woman is prescribed deuretics and given infusion therapy using water-salt solutions.

When Oxytocin and any vasoconstrictor drugs are used, arterial hypertension may appear, that is, high arterial pressure. But this does not always happen; the situation is controlled by the hospital doctor on duty. When combining Oxytocin with Cyclopropane and Halothane, sinus bradycardia and AV rhythm were observed.

In gynecology, "Oxytocin" is successfully used for medical abortion in the second and third trimesters of pregnancy, if there are strong medical indications for removing the fetus from the uterus - a frozen pregnancy or an atypical course of fetal development. For this purpose, a council of medical personnel headed by the attending physician gathers and a decision is made on how to save the life and health of the pregnant woman.

It is important to remember that the drug will not cause pregnancy failure if it is administered very early in a woman’s pregnancy. In this case, the attending physician may prescribe more effective drugs, for example, "Mifepristone" or "Misoprostol".

In large gynecological clinics, the active substance of the drug "Oxytocin" is used through infusion pumps. Such equipment transmits a strictly dosed microportion of a substance through a vein or injects it at a certain time interval. Oxytocin should not be used at home to terminate pregnancy. The dosage and concentration are prescribed only by the attending physician, based on the tests obtained and general condition pregnant woman. If, even in the early stages, you use this active hormone without the supervision of a gynecologist, you can get infertility or create a danger to your life and health. "Oxytocin" is used to terminate pregnancy only by those medical institutions, which have the appropriate certificate.

The hormonal drug has contraindications for use - it is oblique or transverse location fruit, cardiovascular diseases, gestosis, as well as narrow pelvis women in labor. It is not used if the functioning of the kidneys or liver is impaired, there is uterine carcinoma or inflammation in the pelvic organs. When was delivery previously used by caesarean section, “Oxytocin” should not be taken, as the active substance can rupture the uterus with too strong contractions.

In medicine, there have been cases where, after using Oxytocin, fetal remains remained in the uterus. They were removed by surgeons by removing embryonic tissue. Such cases are rare. In gynecology, the remedy is considered the most effective and safe than abortion in terminating an unwanted pregnancy. But doctors always take into account the patient’s risk of afibrinogenemia or large amounts of blood loss.

After using the drug there may be side effects in the form of nausea, vomiting, shock, cardiac arrhythmia, tetanus, hypertonicity or uterine spasm. A woman should report these symptoms to her doctor. Only he is responsible for the health and life of the pregnant woman when using Oxytocin.

The hormone "Oxytocin" interacts in cognitive processes with mental phenomena occurring in the brain. It is a mediator, so when used, a woman begins to feel a decrease in the level of mental activity of the brain structures.

Interestingly, “Oxytocin” is considered the love hormone. It is produced in mammals for their further attachment to their offspring. A person, thanks to this substance, falls in love and is emotionally dependent on his other half.

If an unwanted pregnancy occurs, you must first be examined by a gynecologist and tell him about your desire to interrupt the process. He will send for change necessary tests to make sure there are no contraindications to medical abortion. Next, the woman goes to the hospital, where qualified doctors will use Oxytocin in the required dosage.

Pharmacodynamics

What is Oxytocin? Wikipedia gives the following definition: oxytocin is a hormone hypothalamus . Here the hormone is produced and travels along the axons of neurons of the hypothalamic pituitary tract to the posterior lobe pituitary gland , which serves as a reservoir.

The hormone oxytocin is a protein in nature. It has the ability to stimulate contractions of the uterine muscles at the end of pregnancy and the entire period of labor until delivery. In general, it regulates behavioral responses associated with pregnancy and childbirth.

Currently obtained synthetically. Synthetic, unlike natural, does not contain admixtures of other hormones, therefore it has a more selective effect on the myometrium. Since the drug is free of proteins, it can be used intravenously without fear of anaphylactic effects. The mechanism of action is related to the effect on cells myometrium : membrane permeability for potassium ions increases and excitability increases. The frequency and duration of uterine contractions increases. Stimulates milk secretion, enhancing hormone production (lactogenic hormone) and increasing the contraction of cells of the lactating mammary gland. Has an unexpressed antidiuretic effect. Has virtually no effect on blood pressure.

Pharmacokinetics

After intravenous administration, the effect appears immediately and gradually decreases (up to 1 hour); with intramuscular administration, the effect appears after 3–5 minutes and lasts from 30 minutes to 3 hours. The effect is individual, which is explained by the density of oxytocin receptors in the muscle cells of the uterus. It is quickly absorbed into the bloodstream through the nasal mucosa. Protein binding is about 30%. T ½ 1-6 minutes, this period is shortened in late pregnancy and during breastfeeding. Metabolized in the liver and kidneys. Excreted by the kidneys.

Indications for use

  • excitation And stimulation labor activity ;
  • labor induction for medical reasons ( Rhesus conflict , , post-term pregnancy , intrauterine fetal death, premature rupture of water);
  • prevention of bleeding after or after curettage;
  • incomplete abortion ;
  • acceleration of uterine contractions in the early postpartum period;
  • increased contraction of the uterus during (injection is performed after removal of placenta);
  • premenstrual syndrome, which is accompanied by edema and weight gain;
  • hypolactation after childbirth.

Contraindications

  • increased sensitivity;
  • high blood pressure ;
  • severe disorders of the cardiovascular system;
  • impending uterine rupture ;
  • discrepancy between the sizes of the fetus and the pelvis of the woman in labor;
  • the presence of postoperative scars on the uterus;
  • transverse and oblique position fetus;
  • narrow pelvis;
  • suspicion of placental abruption ahead of time;
  • placenta previa;
  • intrauterine fetal hypoxia ;
  • hypertensive contractions of the uterus;
  • heavy preeclamptic toxemia .

Side effects

  • nausea, vomiting;
  • allergic reactions;
  • and bradycardia;
  • increased blood pressure;
  • urinary retention;
  • excessive labor, which entails premature detachment placenta and risk of uterine rupture;
  • subarachnoid bleeding e;
  • decline fibrinogen in the fetus;
  • neonatal jaundice .

Oxytocin injections, instructions for use (Method and dosage)

The drug in injection form is administered intravenously or intramuscularly.

Instructions for use of Oxytocin

During childbirth, 0.5-2.0 IU of oxytocin is used intramuscularly to induce labor. Injections can be repeated every 30-60 minutes. If there is a need for drip administration of the drug, then 1 ml (5 IU) is diluted in 500 ml of 5% glucose solution. First, inject at a rate of 5-8 drops per minute, then, depending on labor activity, increase the speed to a maximum of 40 drops per minute.

With the aim of prevention of bleeding after childbirth on the first day, 5-8 IU is prescribed intramuscularly three times a day for 3 days. During a caesarean section, injections of 3-5 IU are given into the wall of the uterus (after the fetus is removed). An overdose of oxytocin during childbirth can cause jaundice of newborns , conditioned drug hemolysis .

Instructions for use for animals

There is a veterinary drug that contains 5 or 10 units in 1 ml oxytocin . In veterinary medicine, it is used for prolonged labor in animals, retained placenta, postpartum uterine bleeding, for treatment endometritis , agalactia (lack of milk) and mastitis .

One-time use: dogs administered - 5-10 units depending on weight, cats - 2-3 units. For quick effect intravenous administration of glucose solution is practiced, in which case the dose is reduced by 30%. Repeated administration is possible, but the response to the drug decreases with each administration.

Oxytocin for abortion

Oxytocin has abortifacient - causes contractions and provokes miscarriage. Its use for this purpose is permissible for periods of up to 4-5 weeks, but more often gynecologists use And .

Oxytocin is also used during pregnancy from 14 weeks during induced abortion for medical reasons (frozen pregnancy, developmental defects in the child). The drug is injected into the cervical area after administration Mifepristone And Misoprostol , if the miscarriage was not complete or with an incomplete spontaneous miscarriage, but intravenous infusions are more often performed. However, in the second trimester the drug often causes hypertonicity of the uterus . Even with adequate use, hypertensive contractions of the uterus can occur due to its increased sensitivity to oxytocin.

Medical abortion It is carried out only in a medical institution under the supervision of a doctor, monitoring the contractile function of the uterus and the general condition of the woman. The doctor must make sure that the fertilized egg has left the uterine cavity. In addition, the procedure is dangerous due to bleeding.

The dosage of Oxytocin for termination of pregnancy is determined by the doctor, since the frequency of uterine contractions and their duration depend on it. Women who have , abnormalities of the uterus , scars on the neck abortion Oxytocin contraindicated.

Overdose

It manifests itself as symptoms of uterine hyperstimulation, which leads to tetanic contractions, rupture, and bleeding. The fetus has bradycardia , hypoxia And asphyxia , birth injuries.

If symptoms of overdose appear, immediately stop administering the drug, reduce fluid administration, prescribe diuretics, hypertensive saline solutions, barbiturates.

Interaction

The drug potentiates the vasoconstrictor effect of sympathomimetics. Use with caution with And , as the risk increases arterial hypotension .

Inhalation agents For weaken its effect on the uterus. Prostaglandins enhance its stimulating effect. Use with MAO inhibitors poses a risk arterial hypertension .

Terms of sale

Dispensed by prescription.

Storage conditions

At a temperature of 4-15° C.

Best before date

Analogs

Oxytocin-Vial , Oxytocin-Ferein , Oxytocin-Grindeks , Oxytocin-Richter , Oxytocin-MEZ , Pitocin , Syntocinon .

Vasopressin and Oxytocin

This is also a hormone synthesized by neurons of the hypothalamic nuclei, like oxytocin. They have much in common in their structure, but have different physiological effects. Vasopressin, or antidiuretic hormone , renders antidiuretic And vasoconstrictor effects . Main function- increased reabsorption of water in the kidneys during a decrease in blood pressure or circulating blood volume.

Reviews about Oxytocin

Oxytocin - what is it? Oxytocin is the “love hormone”; it is not for nothing that it is called that, since increased levels are determined in women and men during the period of falling in love. It helps to strengthen emotional and sexual affection and tenderness between representatives of different sexes. This has been repeatedly proven in studies: injection of a nasal spray leads to increased sexual desire, improved sex life. In addition, it is called the “elixir of trust.” Persons with increased level of this hormone, they are inclined to trust other people, become more kind and open.

Especially high level hormone is produced in women at the time of childbirth - this condition can be called an “oxytocin explosion”. Thus, when feeding, oxytocin is produced, since the sucking reflex contributes to its formation. This speeds up uterine contractions and reduces the risk of postpartum hemorrhage. The hormone helps strengthen the bond between mother and baby and determines the maternal instinct, increased care and tenderness towards the child. A slightly smaller “explosion” of oxytocin is observed during orgasm.

An interesting fact is that a nasal spray containing oxytocin reduces appetite and desire for food. fatty foods. The researchers found that the volunteers consumed less food after using the spray. Currently, research is ongoing into the effect of oxytocin on the brain activity of autistic children. Because activation of those areas of the brain that are depressed in these children was detected.

Another study noted similar effects of alcohol and oxytocin on human behavior. acting on different receptors, they cause similar changes in GABA in limbic structures, which are responsible for the perception of stress and anxiety. This hormone reduces feelings of anxiety and fear, and on the other hand, provokes rash actions and causes aggressive and risky behavior.

What foods contain oxytocin? Can it be replenished by eating? The hormone oxytocin is not contained in food, so it does not enter the body from the outside. It has only been established that eating dates stimulates its synthesis during pregnancy and childbirth. Taking dates containing more than 10 elements, a large number of fructose is recommended a few days before birth. Stimulate the release of this hormone by stroking and hugging, the pleasant voice of a partner, massage of the feet and earlobes.

For many years, the drug has been the most effective for stimulating weak labor, treating uterine bleeding, and for medical termination of pregnancy, therefore it is often used in obstetric and gynecological practice. Analyzing the reviews, we can conclude that the drug was indeed prescribed to many during childbirth and after it. Some women experienced a sharp increase in contractions and, accordingly, pain, and some “did not respond” to the administration of the drug - this depends on individual sensitivity.

Now that we have figured out what it is, we have learned about the indications, contraindications and side effects as a preparation, it must be said that experimenting at home and trying to break early pregnancy Oxytocin not safe. In essence, this is a criminal abortion, and the consequences of using the drug for this purpose are unpredictable: loss reproductive function, bleeding of varying degrees and even death. In addition, it is impossible to purchase this drug at a pharmacy, since you need a prescription in Latin, written by a doctor. To preserve your health, use legal methods of terminating a pregnancy!

This drug is used for animals, and in this case you need to know what dosages are used in veterinary medicine. Questions about this are often asked on forums. Eat general rules use of the drug. It is used only after the birth of the first puppy or kitten, when the cervix is ​​dilated, otherwise it can cause uterine rupture. If it does not work, you cannot take a second dose. It is contraindicated to speed up labor by giving injections after the birth of each puppy. It is not recommended to give injections if the dog is pushing to no avail and you suspect that the puppy is “stuck”. During childbirth, 0.3-0.4 ml is injected intramuscularly into a cat; if there is weakness in labor and protracted labor, there is doubt that not all kittens were born. If the drug was not used during childbirth, it is administered after the end of labor in a dose of 0.3 ml. The dosage for dogs is 1-2 ml depending on weight.

Oxytocin price, where to buy

You can buy the drug in Moscow at any pharmacy. The price of ampoules of Oxytocin 5 IU 1 ml No. 5 ranges from 54 rubles. up to 65 rub. Buy a spray as well Oxytocin in tablets (it is represented by the drug Desaminooxytocin , Demoxytocin , Sandopart ) V currently does not seem possible.


The birth of a child is a joyful event. But sometimes you have to give it up various reasons. Future mother may become ill with a disease that will cause complications on the embryo. The embryo may not develop properly from the very beginning. It is not uncommon, of course, for situations when a woman does not want to have a child. this moment for financial or personal reasons. The drug Oxytocin is used to terminate pregnancy along with other methods.

Oxytocin, what is it?

The hormone oxytocin is present in the human body. It is produced by the hypothalamus. The substance is then sent to the pituitary gland, from where it enters the blood under the control of the endocrine gland. The hormone is very important for the process of childbirth. Under its influence, the uterus begins to contract more strongly, its cervix opens and the baby is born.

Due to positive influence hormone for childbirth, it is used for weak labor. Scientists were able to synthesize Oxytocin chemically. Now it is administered to women in labor, young mothers, and used for early abortion. After childbirth, under the influence of the hormone, the woman produces milk to feed the baby.

Oxytocin drug

Action of the drug

Oxytocin in ampoules has the same effect as the natural hormone of our body:

  • The product affects psychological condition person. Oxytocin is called the hormone of happiness. He is responsible for good mood. After childbirth, when some women experience postpartum depression, the drug helps the young mother regain her joyful mood.
  • The natural production of oxytocin occurs mainly at night, so most women in labor give birth to a child at this time.
  • The medicine awakens the maternal instinct in an inexperienced primigravida young woman. A mother begins to love her child immediately after his birth.
  • In the early stages of pregnancy, under the influence of the drug, the fertilized egg is rejected from fallopian tube along with a small amount of blood. The egg does not enter the uterus.
  • This method of getting rid of the fetus is used when there is a danger of the onset of inflammatory processes in a pregnant woman.
    At later stages, Oxytocin for abortion causes premature birth. Under its action, the cervix opens, and the uterus begins to contract vigorously, pushing the embryo out.
  • After timely childbirth and after abortion, the medicine is used in the absence of tone in the uterus, to contract it and prevent bleeding. Under its influence, the uterus gradually takes on the size it had before pregnancy.

The drug acts very quickly - uterine contractions begin 5 minutes after the administration of Oxytocin. Its effect on the uterus lasts for 2 – 3 hours. During termination of pregnancy, vaginal discharge begins 1 hour after taking the medicine. In this situation, medical supervision is necessary.

Indications for use

The drug is used to terminate pregnancy. The use of the drug for abortion means that the woman may begin to bleed, which lasts from several hours to several days. During this period, you must continue to give injections. During pregnancy, oxytocin is injected once a day. After the first injection, the woman needs to move. During movement, the medicine begins to work more actively. If a lady feels severe pain, the doctor will recommend a more gentle set of movements. A specialist will advise you on how to take Oxytocin to terminate pregnancies.

The instructions explain that with the assistance of Oxytocin, it is possible to terminate pregnancy at long term- up to 22 weeks. This is possible with sufficiently compelling motivation to terminate the pregnancy. Motives include:

  • Incurable pathologies of the fetus or severe illness of the mother;
  • Death of the fetus in the womb (the fetus froze);
  • Chromosomal pathologies;
  • Heavy bleeding in a pregnant woman;
  • Complications that threaten the life of a pregnant woman.

At the 20th week, a woman already has little man. You need to understand that abortion cannot be delayed until this date. It’s easy to disrupt a pregnancy, but then it’s difficult to get along with your conscience.

The medicine is prescribed after childbirth for the purpose of removing the remnants of the placenta from the mother’s body. It is also prescribed after an abortion if the uterus is not completely emptied. All residues after childbirth or abortion are released when the uterus contracts through the birth canal. If a pregnant woman's tests reveal protein, if her blood pressure suddenly increases, she is prescribed Oxytocin.

You cannot prescribe treatment for yourself. If there is bleeding or miscarriage, call ambulance, the doctor from which will administer the drug to the pregnant woman or decide to send her to the hospital. Bleeding is a very serious symptom that is difficult to stop. A specialist monitors the patient’s condition during this period.

Side effects of Oxytocin injection

After the hormone injection, the patient may experience a drop in blood pressure and heart rate. In addition, the following side effects are possible after taking Oxytocin to terminate a pregnancy:

  • The occurrence of nausea, turning into vomiting;
  • Poor blood circulation in the brain;
  • Brain hemorrhage;
  • Spasmodic condition of the bronchi;
  • Allergic reaction up to anaphylactic shock.

When side effects physician intervention is necessary. The specialist will decide whether to continue treatment and what to replace the prescribed drug with.

Contraindications to taking the medicine

For some pathological conditions the use of Oxytocin is contraindicated. These include:

  • Ectopic pregnancy;
  • After a caesarean section or with a history of uterine surgery;
  • The placenta is too low and overlaps the cervix;
  • Individual hypersensitivity or intolerance to the drug.

The doctor takes into account the above situations when prescribing. If you start injecting yourself with Oxytocin yourself, this can lead to dire consequences. Stopping bleeding that occurs is beyond the capabilities of a woman without medical education.

Dosage

To terminate a pregnancy in the early stages, injections are given in the area of ​​the cervix. Sometimes the obstetrician-gynecologist decides to give an injection intravenously. The required dose is determined by the duration of pregnancy, the patient’s well-being, and the specific situation.

Usually, in the short term, the dose for one injection is 1 IU. It can increase to 3 IU, but in this case the medicine must be administered using a dropper. When carrying out a dropper, the permissible rate of taking the medicine is up to 30 drops per minute. For drip administration, a glucose solution is taken and Oxytocin is added to it. You can also inject the drug intramuscularly. Taking pills is not effective enough.

Oxytocin tablets are not sold in pharmacies. It is available in ampoules of 5 - 10 IU. There are 5 pieces in the package. Analogues of the drug are Oxytocin-Ferein, Oxytocin-Vial, Oxytocin-Richter, and other drugs.

Is it possible to terminate an unwanted pregnancy with oxytocin or another similar drug? These questions are often asked by girls who, for some reason - out of fear that they will find out about their situation or because financial difficulties, trying to find a way to cause a miscarriage on their own. Well, some women consider it acceptable to terminate pregnancy directly with oxytocin tablets, since this drug used by doctors to induce contractions during incomplete abortion and even during childbirth with weak labor.

But medical abortion with oxytocin is not performed. For these purposes, other drugs are used, those that cannot be purchased freely at the pharmacy. And not all clinics and doctors have the right to perform abortion using pills, but only those who have a license to do so. The drugs used to terminate pregnancy are a progesterone antagonist (mifepristone) and prostaglandin (misoprostol) - it induces labor. So, doctors clearly answer the question “do they use oxytocin to terminate early pregnancy” - no, only misoprostol. And that only after taking mifepristone. Otherwise, the drug may not work. And that's why. Mifepristone suppresses the action of progesterone, a hormone that is absolutely necessary for the development of pregnancy. This has a negative effect on the endometrium and at the same time leads to the fact that the muscular layer of the uterus becomes sensitive to prostaglandins. It begins to contract more often and stronger. At the same time is running cervical ripening. And then, 36-48 hours after mifepristone, the woman takes misoprostol, and literally within an hour she begins to have productive contractions.

Of course, medical abortion costs money. This includes examinations before and after a miscarriage, and the cost of medications, which are not cheap. But nevertheless, it is better to spend money than to experience the consequences of using oxytocin as abortion pills. These will be severe pain in the area of ​​the uterus, contractions, but they are unlikely to lead to a miscarriage. The body is not ready for it. And even if they do, it’s not at all a fact that the miscarriage will be complete. And without medical care still can't do it. Don't risk your health.

By the way, there are contraindications to the use of oxytocin to terminate pregnancy, even in the second trimester. These are placenta previa (as severe bleeding is possible), gestosis, cardiovascular diseases, including hypertension.

In the first trimester, taking the drug is possible only under medical supervision and only after taking mifepristone and misoprostol, if the miscarriage was not complete. Or in case of incomplete spontaneous miscarriage, so as not to clean the uterus.

Active substance: Oxytocin

Manufacturer: Microgen, Russia

Conditions for dispensing from a pharmacy: On prescription

The drug Oxytocin is synthetic hormonal agent, which is used to increase the tone of the uterus and activate the contractile function of the myometrium, which, in turn, stimulates labor.

Indications for use

Oxytocin is injected for the purpose of:

  • Stimulation of labor in the first and second stages of labor when contractions are not strong enough
  • Labor induction during delay intrauterine development in a child with severe gestosis, premature rupture membranes and outpouring amniotic fluid, fetal fading, very post-term pregnancy (more than 42 weeks), Rh conflict
  • Prevention, as well as treatment of bleeding that occurs after childbirth, cesarean section, and also after abortion
  • Carrying out additional therapeutic therapy with a failed abortion or after an incomplete miscarriage.

A 1 ml ampoule contains active ingredient– oxytocin along with a number of additional substances:

  • Acetic acid
  • Ethanol
  • Chlorobutanol hemihydrate
  • Purified water.

Medicinal properties

The INN (international nonproprietary name) of the drug is the same as the name of the hormone that is produced in human body and promotes normal course childbirth, stimulates uterine contractions during the postpartum period. In Latin, the name of the medicine sounds exactly the same as in Russian.

If we consider the pharmacological groups of drugs, then oxytocin belongs to the hormones of the hypothalamus (pharmaceutical group of gonadotropins, antagonists and uterotonics).

A hormone of protein nature, the mechanism of action is based on stimulating contraction of the muscular structure of the uterus in last trimester pregnancy until the onset of childbirth. It corrects behavioral reactions that are directly related to pregnancy and childbirth.

Today, oxytocin is produced synthetically; the hormone analogue does not contain any impurities, so its effect on the myometrium is selective. Since the synthetic hormone is free of beks, it is indicated for intravenous use and does not have an anaphylactic effect. The action of oxytocin is associated with special mechanisms of influence on myometrial tissue, due to which the permeability of cell membranes for K ions increases, along with this their excitability increases. Both the frequency of uterine contractions and their duration increase significantly.

The pharmacological group of the drug explains its effect on secretion breast milk. Under the influence of the hormone, the production of prolactin significantly increases, and the contraction of cells located in the mammary glands increases. The drug has a weak antidiuretic effect. However, it does not affect blood pressure.

Pharmacokinetics

After injection into a vein, the medicine begins to act instantly, the effect of use gradually decreases over 60 minutes. When injected into a muscle therapeutic effect can be assessed after 3-5 minutes, it persists for 0.5-3 hours. It is worth noting that the effect of the drug on the body is individual, this is explained by the density of the so-called oxytocin receptors of muscle cells located in the uterus.

Quite quickly, the solution enters the general circulation due to absorption through the mucous membranes of the nasal passages. The connection with albumin is at the level of 30%. The half-life is about 1-6 minutes, it is reduced by later pregnancy and lactation. Metabolic processes occur in the cells of the liver and kidneys. Metabolites are excreted by the renal system.

Release form

Price from 23 to 76 rubles.

The injection solution is transparent and completely colorless without any inclusions or impurities, available in 1 ml ampoules. In a cardboard box, the ampoules are placed in a cell package (5 pcs.) along with instructions.

Oxytocin: instructions for use

The use of oxytocin (injections) to induce insufficient labor in the 3rd trimester is possible only as prescribed by a doctor. Oxytocin is administered intramuscularly using a dose of 0.5-2 IU. Each injection of the drug is administered at intervals of 30-60 minutes. If drip administration of a hormonal drug is required, in this case 1 ml of solution should be diluted with 500 ml of a 5% glucose solution. Before use it is necessary to exclude increased sensitivity to synthetic oxytocin. On the first day, the hormone is administered at a low rate - 5-8 drops. in one minute, depending on the observed effect, the speed can be increased to 40 drops. in a minute.

To prevent uterine bleeding in the postpartum period, during the first day, 5-8 IU of oxytocin is prescribed, it is injected into the muscle three times a day in a course of 3 days. If there are no side effects, the administration of the drug on day 3 should be final. It is worth checking with your doctor exactly how many injections are needed in a particular case. During a caesarean section, injections are placed inside the uterine wall, the dosage is 3-5 IU, the procedure is carried out immediately after the baby is removed.

In parallel, they can be appointed hormonal creams and ointments. How to use hormonal ointment, you need to check with your doctor.

Oxytocin for abortion

If you use Oxytocin during pregnancy, especially in the early stages, cramping pain begins, resulting in a miscarriage. It is worth noting that medical termination of pregnancy must take place under strict medical supervision. The decision about whether oxytocin therapy can be started is made taking into account the patient’s medical history; it is impossible to accurately predict how quickly the drug acts to terminate pregnancy in the early stages.

It is possible to use oxytocin from 14 weeks. for the purpose of carrying out induced abortions, termination at such periods is carried out for medical reasons (fading of the fetus, severe malformations in the fetus). The drug is used by injecting a solution into the cervix after taking a Mifepristone tablet or Misoprostol, if the medical abortion was accompanied by complications (incomplete excretion ovum) or with incomplete spontaneous miscarriage. Often, infusion is administered into a vein. But even the use of a standard dosage of the drug is fraught with uterine hypertonicity. If injections were given, following the instructions for the drug, hypertensive contraction of the uterus is possible due to the development of excessive susceptibility to oxytocin.

The dosage of the drug is selected by the doctor; the amount of oxytocin administered affects the intensity of uterine contractions, as well as their duration. During an abortion, it is important to control the woman’s condition; in the abortive action, it is worth taking into account Negative consequences For female body, high risk of occurrence hormonal imbalance. The decision to terminate a pregnancy or not must be balanced, because the woman’s health depends on it.

Oxytocin after medical abortion promotes better contraction of the uterus and rapid restoration of its size (as described in the instructions for use). After medication interruption pregnancy and the use of oxytocin, you should start taking antibiotics to prevent the development of infection in the uterus. Even if there are no signs of infection after an abortion, it is still worthwhile to carry out antibacterial therapy; the dosage is calculated individually.

Contraindications

  • Increased uterine tone that did not develop during delivery
  • The presence of serious contraindications for natural childbirth
  • Emergency cases that require immediate surgical intervention
  • Development of arterial hypertension
  • Severe form of gestosis
  • Facial presentation or when squeezing the baby
  • Strong stretching of the uterine walls
  • Serious ailments of the cardiovascular system
  • Impaired functioning of the renal system.

There are no other contraindications for use.

Precautionary measures

Terminating a pregnancy at home is strictly prohibited. If a woman injects the drug on her own, she should seek help from a doctor as soon as possible. antenatal clinic, home use hormonal drugs for several days can lead to irreparable consequences. At home interruption During pregnancy, taking pills and giving injections even with slight uterine bleeding is fraught with complications, including death.

Before having an abortion, you should consult your doctor and find out about the possible consequences for your own health.

Patients suffering from disorders of the cardiovascular system, medicine should be used with caution.

In case of uterine bleeding that occurs after the injection, you should urgently consult a doctor.

Cross-drug interactions

When using Oxystocin solution and drugs used for inhalation anesthesia, the therapeutic effect of the synthetic hormone may decrease and the risk of arterial hypotension increases.

When used with hormonal drug prostaglandin agents, drotaverine hydrochloride and other antispasmodics, suppression of the effect of oxytocin is observed.

Side effects

Before injecting oxytocin, you should familiarize yourself with what reactions the drug can provoke:

  • Severe nausea and vomiting
  • Manifestations of allergies
  • Sharp jump in blood pressure
  • Urinary retention
  • Decrease in fibrinogen in a baby
  • Development of arrhythmia or bradycardia
  • Excessive stimulation of labor, which leads to placental abruption, which increases the likelihood of uterine rupture
  • The occurrence of neonatal jaundice
  • Discovery of subarachnoid hemorrhage.

Overdose

In case of overdose, excessive contraction of the uterus is observed, which leads to bleeding and uterine rupture.

If signs of hyperstimulation on oxytocin are observed, it is worth stopping its administration, reducing fluid intake, and ensuring the intake of diuretics and hypertonic solutions. There is no other treatment for overdose.

Storage conditions and shelf life

Ampoules with the solution should be stored at a temperature of 4-15 C for 2 years.

Desaminooxytocin

Oxytocin tablets are used for the same purposes as the solution. The use of the drug is recommended to stimulate the contractile function of the uterus and during early postpartum period to stimulate lactation. The tablet contains a powder that is difficult to dissolve in liquid and is resistant to the action of enzymes that destroy oxytocin.